产品货号：
Z12097
中文名称：
BRCA2抗体
英文名称：
Anti-BRCA2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRCA2 Antibody |
| 指标别名 | BRCA2;BRCC2;breast cancer 2;early onset;BROVCA2;FACD;FAD;FAD1;FANCB;FANCD;FANCD1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | BRCA2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human BRCA2(2220-2236aa ENYFETEAVEIAKAFME),identical to the related rat sequence,and different from the related mouse sequence by one amino acid. |
| 实际分子量 | 384KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BRCA2 is a human tumor suppressor gene(specifically,a caretaker gene),found in all humans.This gene is mapped to 13q13.1.BRCA2 is essential for efficient homology-directed repair,it regulates both the intracellular localization and DNA-binding ability of RAD51.What's more,the complete BRC repeat domain of BRCA2 shows robust RAD51 binding and it is a critical cofactor for RAD51-mediated homologous recombination.BRCA2 is also a key mediator of homologous recombination and provides a molecular basis for understanding how this DNA repair process is disrupted by BRCA2 mutations.BRCA2-deficient cells,as a result of their deficiency in homologous recombination,are acutely sensitive to PARP inhibitors. |
| Uniprot ID | P51587 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | breast cancer 2,early onset |
| 蛋白名全称 | Breast cancer type 2 susceptibility protein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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